Build the Enrollment Plan You Can Actually Defend

Only 20% of clinical trials finish on time. ProofPilot's Enrollment Forecaster replaces spreadsheet models and manual site estimates with sponsor-owned scenario planning — grounded in 400,000+ comparable trials across 62 countries, so your team builds a defensible forecast before a single site activates.

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A 730-Day Enrollment Window, Reshaped Before Day One

A top-10 pharma sponsor's Phase III cardiovascular program, stress-tested against real-world data. Enrollment Forecaster surfaced a diversified country mix that reduced time to LPI by 118 days and improved success probability from 85% to 94%.

Validated feasibility

Odds of success increased from original plan

days

Reduced timeline

Faster time to market with a shortened predicted LPI

Lower screen-fail exposure

Reduced projected screen-failure rate with optimized enrollment selection

Reduce 5 Weeks of Feasibility Work to Just 5 Minutes

AI-Powered Clinical Trial Forecasting that Thinks Ahead - So You Don’t Fall Behind

ProofPilot _ Website Imagery 2026_Planning Forecaster

ENROLLMENT FORECASTER

FORECAST SIMULATE COMPLEX MODELING

FORECAST WITH PRECISION - DOWN TO THE SITE LEVEL

Model site activation, screen failures, discontinuation rates, and non-enrolling sites with forecasts that adapt by country, region, and indication.

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QUANTIFY UNCERTAINTY, NOT JUST OUTCOMES

See confidence intervals and scenario comparisons built from real-world trial data and Monte Carlo simulations—so you can measure and mitigate risk.

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ADJUST IN REAL TIME

Model protocol amendments, eligibility criteria changes, or country swaps—without restarting from scratch.

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Forecast Enrollment with Confidence

Replace static feasibility models with adaptive, AI-powered forecasts — so sponsors can pressure-test scenarios, quantify risk, and commit to realistic timelines before kickoff.

SCENARIO MODELING

Complex enrollment structures & "what if" scenarios
Configure by Key Dates, Rates, and Pauses

ENROLLMENT SIMULATION

Over 10,000 simulations conducted instantaneously
See your trial playout across Country, Site, and overall study performance

MULTI LEVEL PLANS

Create plans Globally, Regional, by Country , and by Site
Unique projections down to the site level

BENCHMARK DATASET

Built on proprietary data from over 500,000 trials
Ensures a user-friendly experience for improved engagement

Frequently Asked Questions

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What is the ProofPilot Enrollment Forecaster?

The ProofPilot Enrollment Forecaster is a sponsor-owned forecasting tool that helps clinical operations teams evaluate multiple scenarios and build a defensible clinical trial enrollment forecast before a study begins. It draws on a benchmark dataset of over 400,000 historical site performance records globally, giving sponsors the data they need to justify inputs like Regulatory Approval, Site Ready curves and screen failure ratios to build evidence based clinical trial enrollment forecasts with confidence from day one.

Who is the Enrollment Forecaster designed for?

The Enrollment Forecaster is built for sponsor clinical operations teams, feasibility leads, and program managers responsible for building and defending enrollment forecasts. CRO partners executing planning on behalf of sponsors also use the platform, giving both teams access to the same sponsor-configured projections.

How does the Enrollment Forecaster generate projections?

The Forecaster builds projections using an algortihm based on sponsor-provided assumptions, historical benchmark data, and Monte Carlo simulations. Sponsors are always in control of the final inputs and can rapidly generate multiple scenarios, adjusting variables to arrive at a defensible enrollment forecast.

What data does the Enrollment Forecaster use?

The Forecaster draws on a benchmark dataset of over 400,000 historical golabl clinical trial. Sponsors layer in their own study assumptions on top of this benchmark to build projections that reflect both market reality and study-specific context. The benchmark data remains within ProofPilot and feeds directly into the platform's enrollment tools. Sponsor data can also be fed into the tool for additional power and efficiency.

How does the Enrollment Forecaster integrate with existing systems?

The Forecaster is designed to complement your current CTMS and planning tools. It layers onto your existing stack and the data sponsors bring in feeds directly into ProofPilot's enrollment tools—so teams build and defend enrollment projections in one place and carry that intelligence forward into execution without switching platforms.

Is the Enrollment Forecaster compliant with clinical trial regulatory requirements?

Yes. ProofPilot's platform is built for regulated environments and is 21 CFR Part 11, HIPAA, GDPR, and GxP compliant. The Forecaster produces inspection-ready outputs with full documentation of assumptions, data sources, and scenario configurations, so sponsors can defend projections in internal reviews and regulatory submissions.

What Our Clients Say

ProofPilot has taken a more holistic approach without being a heavy weight “platform” and frankly it’s refreshing!

-Top 10 Pharma Client

I really appreciate this portal. This scheduling method works best for me because I see patients during the day and sometimes the schedule varies.

-Vicky Sudan, Study Coordinator, Colorado Neurology and Headache Center

I would love to use ProofPilot in other studies. It is much more efficient...especially when you have multiple studies going on.

-Bethany Dunn, Recruitment Coordinator, Flourish Research

This would be so helpful if patients from every study was using it!

-Coordinator, Global Medical Research

Through integrated workflows to ensure timely training, logistics and patient payments, we saw nearly 90% compliance from our participants

-Digital Health Researcher

We used PROOFPILOT to enroll 300 patients for DCT digital biomarker study – it delivered enormous cost savings, quality data, and great compliance.

-Top 20 Pharma Client

Build the Enrollment Plan You Can Actually Defend

A 730-Day Enrollment Window, Reshaped Before Day One

Reduce 5 Weeks of Feasibility Work to Just 5 Minutes